The Influence of Lipid Tail Composition on Bid-Mediated Bax Pore Formation
نویسندگان
چکیده
منابع مشابه
Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation.
Mitochondrial outer membrane permeabilization (MOMP) is a critical step in apoptosis and is regulated by Bcl-2 family proteins. In vitro systems using cardiolipin-containing liposomes have demonstrated the key features of MOMP induced by Bax and cleaved Bid; however, the nature of the "pores" and how they are formed remain obscure. We found that mitochondrial outer membranes contained very litt...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2020
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2019.11.2236